Ernawati Sinaga, - and Suprihatin, - and Ida Wiryanti, - (2011) PERBANDINGAN DAYA SITOTOKSIK EKSTRAK RIMPANG 3 JENIS TUMBUHAN ZINGIBERACEAE TERHADAP SEL KANKER MCF-7. Jurnal Farmasi Indonesia, 5 (3). pp. 125-133.
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Abstract
We investigated and compared the cytotoxic activity of ethanolic extract of the rhizome of 3 species of Zingiberaceae plants that grow abundantly in Indonesia, i.e. Zingiber ottensii, Zingiber zerumbet, and Nicolaia speciosa in an in vitro tetrazolium salt assay using human breast cancer cell line MCF-7. The results showed that 2 out 3 extracts showed significant cytotoxic activity. i.e. Zingiber ottensii and Zingiber zerumbet with IC50 value respectively 60 and 50 ug/mL, while the ethanolic extract of Nicolaia speciosa showed considerable larger IC50, i.e. 625 ug/mL. From the results it can be concluded that the rhizome of Zingiber ottensii and Zingiber zerumbet have a good prospect to be further investigated and developed as raw materials for new cancer drug. Keywords: Zingiberaceae, cytotoxicity, anticancer, MTT, MCF-7
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Artikel > Biologi |
| Depositing User: | BPSI Unas |
| Date Deposited: | 29 Aug 2017 17:23 |
| Last Modified: | 29 Aug 2017 17:23 |
| URI: | http://repository.unas.ac.id/id/eprint/166 |
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